| Cypermethrin loaded nanoparticles: a new technology to formulate low risk and durable slow release pesticides for urban pest control |
| Paper ID : 1313-3IICE (R1) |
| Authors: |
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Vahid Derakhsh Ahmadi *1, Babak Heidary Alizadeh2 1Department of Plant Protection, Agriculture college, Islamic Azad University, Arak Branch, Iran 2Department of Pesticide, iripp |
| Abstract: |
| Frequent use of conventional pesticides has caused a number of environmental and health issues and it is supposedly responsible for pest resistance occurrence. There is a huge ongoing investigation to tackle the problem of pesticides amongst which, the nanotechnology has proven to be one of the most important fields of research. The impressive progress in nanotechnology has inspired chemists to develop especial nanoparticles aiming to provide designed properties for specific purposes, including pesticides. In general, the nanoparticles are prepared by reaction of lactic (LA) and glycolic acid (GA) monomers to obtain poly (d,l-lactide-co-glycolide) (PLGA) copolymer which encapsulates the pesticide in a neutral condition. Therefore, in a process DL-lactic acid and glycolic acid reacted together in presence of ionic exchange resins of Dowex 50 w and heated at 130 ˚C, 150 ˚C and 185˚C, separately. Then, the formed water was removed by reduced pressure. The high-brown solid product was dissolved in dichloromethane and filtered to remove Dowex and, eventually, the solvent evaporation led to an amorphous solid product. Afterwards, the product was collected and dried at reduced pressure. Then, an appropriate amount of cypermethrin (technical) was dissolved in dichloromethane containing sufficient amount of PLGA, followed by adding water to form water-in-oil (W/O) emulsion under continuous stirring. Next, aqueous polyvinyl alcohol solution was added to the W/O primary emulsion. The mixed product was heated at 15 and temperature was gradually raised to 45 ˚C for 60 minutes which gave rise to the cypermethrin nanocapsule formation. The developed cypermrthrin nanocapsules were characterized as spherical with medium size of 230–340 nm using UV-VIS spectrophotometer, DLS, and Transmission Electron Microscope. Results revealed that the nanoparticle technology could be an efficient way to make new formulation for pesticides where a slow release mode is expected to control long life pests such as cockroaches; a delivery system of insecticides which promotes an active ingredient having desirable pest control impacts. |
| Keywords: |
| Pesticide formulation, Nanotechnology, Cypermethrin, Poly lactic acid glycolide, Emulsion, Urban pest control. |
| Status : Paper Accepted (Poster Presentation) |
